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Director/Senior Director/Executive Director, DMPK Biotransformation Leader

This position is based in Shanghai, China, reporting to Head of DMPK Services at WuXi AppTec.

Key accountabilities:

  • As a technical expert, direct in vitro and in vivo biotransformation studies particularly in metabolite identification, structure elucidation, reactive metabolite trapping; and mass balance, tissue distribution, pharmacokinetics and metabolism studies with 14C-radiolabeled compounds in animals using various bioanalytical techniques such as high resolution Q-TOF and Q-Trap LC-MS/MS/UV systems, liquid scintillation analyzer, flow scintillation analyzer and oxidizer.
  • ŸServe as a leader of DMPK representatives in partner medicinal chemistry programs.  Accountability specifically in Structure- Metabolism relationship, DMPK data interpretation, program management, internal collaborations with other functions (chemistry, biology, pharmacology, toxicology, etc.)
  • ŸDirect and manage a functional team of biotransformation and 14C –labeled DMPK
  • ŸIdentify and establish appropriate new capability relevant to biotransformation and 14C –related DMPK studies.
  • ŸServe as a mentor and educator to subordinates as well as promote full career development potential.

Requirements:

  • A Ph. D. degree in drug metabolism, pharmacokinetics, bioanalytical chemistry, mass spectrometry or a related degree with 5 - 15 years' industrial experience.
  • Hands-on experience and skills in drug metabolism, bioanalytical chemistry, mass spectrometry, pharmacokinetics and the instrumentation on ion-trap LC-MS/MS/UV, high resolution LC-MS/MS/UV, liquid scintillation analyzer, flow scintillation analyzer and oxidizer.
  • Strong capability and track record of DMPK representation in support of drug discovery and preclinical programs. A deep understanding in SMR for guiding medchem efforts.
  • Working experience in biotransformation of small molecules in drug discovery, preclinical and early development stages.
  • A proven track record of metabolite identification, structure elucidation and determination studies using non-labeled and 14C-labbeled test compounds in animals and humans
  • Excellent oral and written communication skills
  • Demonstrated management and leadership skills